Effect of Locally Injectable Platelet-Rich Plasma as an Adjunct to Scaling and Root Planing on Salivary MMP-8 Level in Periodontitis Patients

Objective: To assess the effect of platelet-rich plasma (PRP) local injection in the treatment of periodontitis, as an
adjunct to scaling and root planing (SRP).Materials and Methods: Ninety subjects were involved in this study. They
were divided into 3 groups. Group I (negative control) included 30 subjects with healthy periodontium. Group II
(positive control) included 30 periodontit is patients who were treated by SRP planing. Group III (study) included 30
periodontitis patients who were treated with SRP and PRP injections. Plaque index (PI), Gingival index (GI), probing
pocket depth (PPD), and clinical attachment level (CAL) in addition to MMP-8 level recorded at baseline for all groups
and 2 months post-treatment for groups II and III .Results: At baseline; PI, GI, PPD, CAL, and MMP-8 revealed no
significant difference between group II and III (p>0.05), while the periodontal parameters of both groups showed highly
significant higher values versus group I (p<0.001 for each). Both groups showed a highly significant decrease in PI, GI,
PPD, and CAL after treatment (p<0.001 for each). In addition, Group III showed significantly lower values in PI
(P=0.028) and GI (p=0.032) and a highly significant decrease in PPD and CAL (p<0.001 for each) versus Group II.
However, after treatment, both groups II and III showed a highly significant decrease in MMP-8 (p<0.001 and p=0.010
respectively). No significant difference was found in the MMP-8 level between Group II and III as the mean±SD was
1.73±0.58 and 1.9±0.49 respectively. Conclusions: Injection of autogenous PRP in addition to SRP in periodontal
pockets can enhance clinical parameters of periodontitis.