Tissue Engineering and Regenerative Endodontics

The European Society of Endodontology and the American Endodontology Association have published the guidlines and regenerative endodontics clinical issues.Literatures are increasing in this interesting field. In regenerative endodontics, endogenous stem cells with inductive bleeding in periapicalregion and scaffoldsblood clot, platelet rich plasma/fibrin have been utilized. And this path has been demonstrated as a ‘paradigm shift” and considered the first choice of treatment for pulp necrosis immature teeth. There are several steps to successfully originate regenerative endodontic treatment; firstly, clinical chief complain and symptoms resolution, secondly toothroot maturity and thirdly restore of neurogenesis. The outcomes of these objectives are presented to be variable, and real pulp/dentine complex regeneration is a crucial goal that does not achieved yet.There is a previous concept regarding the Repair origin which considered to be primarily from osseous and periodontal tissues. The real regeneration of pulp is hoped to be an achievable goal with the concept of tissue engineering, embarking stem cells, scaffold and moleculessignaling together to achieve regenerative endodontics. This review outlines current and future implementation of regenerative endodontics. Proposed that regenerative endodontic has to be considered a first line of treatment for immature teeth and though teeth with immatureor mature root instead ofconventional endodontic treatment or MTA barrier procedures. For instance, there are still much unknown secrets about clinical and biological aspects until regenerative endodontics practicing dominantly among dentists.In this review we will describe how this compound and different signaling interactions that will impact cellular episodes post injury and provide new curative emulated that utilize the bioactive soluble molecules in dentin/pulp to optimize dentin-pulp complex regeneration.