The effect of non-surgical periodontal therapy on the level of CCL25 in GCF of chronic periodontitis patients

      Chronic periodontitis is defined as “an infectious disorder
 causes inflammation in the supportive tissues of the teeth,
advancing loss of attachment, and  losing of  bone.”(1) Such description illustrates the main clinical and etiological characters of the disorder:
(1) formation of dental pulp (dental plaque); (2) periodontal
inflammation (e.g., gingival swelling with bleeding on probing); and
(3) Clinical attachment loss and alveolar bone loss.
periodontitis may also be associated with a number of
systemic disorders and syndromes. In most cases, patients
with systemic diseases that lead to altered host immunity may
also show periodontal destruction. Therefore, periodontitis is a
disease that is not only limited to the area of the oral cavity; it is
also associated with several systemic diseases (e.g., cardiovascular
disorders, diabetes mellitus).(2)
Although chronic periodontitis is most frequently shown in grownups, it may happen in childhood and teenagers as a reaction to long standing plaques and calculus accumulating.
 
Characteristic clinical picture in cases having non-treated long standing peri-odontitis comprise supragingival and subgingival plaque and
calculus, gingival swelling, redness and loss of gingival stippling,
change in gingival margins (e.g., rolled, flattened, cratered papillae, recessions), presence of periodontal pockets, bleeding on probing, attachment loss(angular or horizontally), alveolar bone loss, root furcation involvement (exposure),increased tooth mobility, Change In Tooth Position and tooth loss