Document Type : Original Article
Abstract
Background: Patients with periodontal diseases have high levels of serum anticardiolipin antibodies (aCLA). Anticardiolipin antibodies are class of antiphospholipid antibodies which cause thrombosis. Increased aCLA concentrations have a modulating role in cardiovascular diseases. The actual target antigen for these antibodies is β2-glycoprotein-I (β2GPI).Aim: of our study was to determine the effect of non surgical periodontal treatment (scaling and root planning) on serum aCLA level in chronic periodontitis patients associated with CAD. Subjects and methods: This study was conducted on forty individuals. Fifteen subjects suffering from chronic periodontitis and CAD were enrolled in the study as study group (group I), fifteen subjects suffering from chronic periodontitis as positive control group (group II) and ten healthy subjects as negative control group (group III). Clinical periodontal parameters (periodontal pocket depth, clinical attachment loss and bleeding on probing, plaque index) were recorded at baseline for all groups at baseline and six weeks after non surgical periodontal treatment for groupIand groupII. Serum samples were taken two times at baseline and six weeks after treatment for groupI and groupII and only once for group III. The patients were treated twice a week for three weeks. The samples were analyzed using Anticardiolipin ELISA kit. Results: All periodontal parameters (PI,BOP,PPD,CAL) and Laboratory analysis results (IgG, IgM, cholesterol, TGS, HDL, LDL) were reduced significantly by non surgical periodontal treatment. Conclusion: Scaling and root planning (SRP) is an effective treatment in chronic periodontitis patients associated with CAD. Successful periodontal therapy can improve the serum level of one of the inflammatory biomarkers (aCLA) which is involved in the cardiovascular problems.
Key words : chronic periodontitis, coronary artery disease, aCLA, β2-glycoprotein-I.
Background: Patients with periodontal diseases have high levels of serum anticardiolipin antibodies (aCLA). Anticardiolipin antibodies are class of antiphospholipid antibodies which cause thrombosis. Increased aCLA concentrations have a modulating role in cardiovascular diseases. The actual target antigen for these antibodies is β2-glycoprotein-I (β2GPI).Aim: of our study was to determine the effect of non surgical periodontal treatment (scaling and root planning) on serum aCLA level in chronic periodontitis patients associated with CAD. Subjects and methods: This study was conducted on forty individuals. Fifteen subjects suffering from chronic periodontitis and CAD were enrolled in the study as study group (group I), fifteen subjects suffering from chronic periodontitis as positive control group (group II) and ten healthy subjects as negative control group (group III). Clinical periodontal parameters (periodontal pocket depth, clinical attachment loss and bleeding on probing, plaque index) were recorded at baseline for all groups at baseline and six weeks after non surgical periodontal treatment for groupIand groupII. Serum samples were taken two times at baseline and six weeks after treatment for groupI and groupII and only once for group III. The patients were treated twice a week for three weeks. The samples were analyzed using Anticardiolipin ELISA kit. Results: All periodontal parameters (PI,BOP,PPD,CAL) and Laboratory analysis results (IgG, IgM, cholesterol, TGS, HDL, LDL) were reduced significantly by non surgical periodontal treatment. Conclusion: Scaling and root planning (SRP) is an effective treatment in chronic periodontitis patients associated with CAD. Successful periodontal therapy can improve the serum level of one of the inflammatory biomarkers (aCLA) which is involved in the cardiovascular problems.
Key words : chronic periodontitis, coronary artery disease, aCLA, β2-glycoprotein-I.
Background: Patients with periodontal diseases have high levels of serum anticardiolipin antibodies (aCLA). Anticardiolipin antibodies are class of antiphospholipid antibodies which cause thrombosis. Increased aCLA concentrations have a modulating role in cardiovascular diseases. The actual target antigen for these antibodies is β2-glycoprotein-I (β2GPI).Aim: of our study was to determine the effect of non surgical periodontal treatment (scaling and root planning) on serum aCLA level in chronic periodontitis patients associated with CAD. Subjects and methods: This study was conducted on forty individuals. Fifteen subjects suffering from chronic periodontitis and CAD were enrolled in the study as study group (group I), fifteen subjects suffering from chronic periodontitis as positive control group (group II) and ten healthy subjects as negative control group (group III). Clinical periodontal parameters (periodontal pocket depth, clinical attachment loss and bleeding on probing, plaque index) were recorded at baseline for all groups at baseline and six weeks after non surgical periodontal treatment for groupIand groupII. Serum samples were taken two times at baseline and six weeks after treatment for groupI and groupII and only once for group III. The patients were treated twice a week for three weeks. The samples were analyzed using Anticardiolipin ELISA kit. Results: All periodontal parameters (PI,BOP,PPD,CAL) and Laboratory analysis results (IgG, IgM, cholesterol, TGS, HDL, LDL) were reduced significantly by non surgical periodontal treatment. Conclusion: Scaling and root planning (SRP) is an effective treatment in chronic periodontitis patients associated with CAD. Successful periodontal therapy can improve the serum level of one of the inflammatory biomarkers (aCLA) which is involved in the cardiovascular problems.
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