Evaluation of Biologic and Some Physical Properties of Flexible Resin Modified with Antimicrobial Nanostructures

Objectives:: The present study was designed to evaluate the impact of addition of different antimicrobial nanostructures to flexible resin versus the conventional heat cured acrylic resin type regarding cell cytotoxicity, surface roughness and impact strength.
Methods:Polyamide and heat cured polymethyl methacrylate were used in this study and both were modified with silver vanadate and titaniananorods at different concentrations. For cytotoxicity test a total number  of  60 disc  shaped  specimens  (30 for  each  type of  resin), were used in  cell vitality test. For Surface roughness, a total number  of  40 disc  shaped  specimens  for both  types of  of resin  was tested using a two dimensional profilometer. For Impact strength, a total number  of  40 rectangular  shaped  specimens  for both  types of  resin   were  prepared and measured using impact testing machine using charpy method. Four way ANOVA test was used for cytotoxicity test and two way ANOVA was used for both surface roughness and impact tests. Means and standard deviations (SD)  was calculated for the tested groups. Statistical analysis was conducted using SPSS version 16 (StatsiticalPackacge for scientific studies). The t test was used for all tests for comparison between groups.
Results:Cytotoxicity of subdivision IAC₄D₂ (heat cured with 1% silver vandate after 48 hrs) was the highest value while IIBC₄D₁ (flexible with 1% titania after 24 hrs) was the lowest value. Surface roughness and impact strength of division IIBC₄ (Flexible with 5% titania) was the highest while division IBC₁  ((heat cured with 0 % titania) was the lowest.
Conclusions:Silver nanorods  have an adverse on cytotoxic effect of  both  flexible and heat  cured  acrylic resins. Titaniananorods are biocompatible materials. They gave no cytotoxic effect with flexible resin. Ttitaniananorods increased the impact strength of both flexible and heat cured acrylic resins. Flexible resin had less cytotoxic effect than heat cured acrylic resin. Flexible resin modified with titaniananorods had higher impact strength and surface roughness than those of heat cured acrylic resin.