BiologicalImpact of Platelet Rich Fibrin and Bovine Bone on Bone Regeneration A histological Study in Guinea Pigs

Background:Improving of bone defect healing is considered a highly challenged process in dentistry which may be affected by several factors such as age, hormonal status and related bone disease. In order to enhance bone healing the administration of bone grafts or autologous concentrate of platelets is widely used which act on increasing bone formation or inhibiting bone resorption..
Objectives: The goal of the research has been to evaluate the effect of Bio-Oss bone graft and platelet rich fibrin on healing of bone tissue in guinea pig through histological and histomorohometic analysis.
Results: Histological and histomorphometric finding showed gradual increase in bone formation in all groups with different degrees.The degree of formation of new bone in study groups has been markedly higher than the control group. Combination group presented higher rate of formation of bone matched to different groups.
Conclusion:: In the current study it was found that, proper application of Bio-Oss bone graft in combination with platelet rich fibrin was excellent approach that gave better enhancement in osteogenesis and acceleration in bone healing than using each one of them separately.