Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma

.Monier, Nehad M; Atteya, Islam M.; Askar, Hamdia; Helmy, Samah

doi:10.21608/mjd.2020.198725

Detection of the periodontal pathogen Porphyromonas Gingivalis in Oral Squamous Cell Carcinoma

Document Type : Original Article

Authors

¹ Teaching assistant of oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt.

² Lecturer of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt.

³ Professor of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt.

⁴ Professor of Oral medicine and periodontology, Faculty of Dentistry, Mansoura University, Egypt

10.21608/mjd.2020.198725

Abstract

Background: The concept of infection-based carcinogenesis is gaining an increasing attention. Also periodontitis has been extensively studied as possible risk factor for gastrointestinal cancers including oral cancer.
Methodology: Using conventional PCR, we detected the presence of the key periodontal pathogen Porphyromonas gingivalis (P. gingivalis) in 25 oral cancer fresh tissue specimens versus 25 healthy oral mucosal tissue..

Results: P. gingivalis showed significantly higher prevalence in control group with slightly higher loads in cancer tissue. Bacterial presence was not found to be correlated with tumor progression.
Conclusion: P. gingivalis was not found to play a possible role in the cancerous lesion. More studies should be implemented to investigate the bacterial involvement in the oral tumors.